Aeglea Bio Therapeutics Inc
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AGLE Aeglea Bio Therapeutics Inc
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Health Care : Biotechnology | Small Cap Value
Company profile

Aeglea BioTherapeutics, Inc. is a clinical-stage biotechnology company. The Company is focused on developing human enzyme therapeutics to benefit people with rare metabolic diseases. The Company’s product candidates include pegzilarginase and AGLE-177. The Company's lead product candidate, pegzilarginase, is a recombinant human arginase one that enzymatically degrades the amino acid arginine to lower arginine levels in patients with Arginase one Deficiency. Its engineered pegzilarginase with modifications that enhance the stability and arginine-degrading activity of the enzyme in human plasma. The Company is evaluating Pegzilarginase in a global pivotal Phase III PEACE (Pegzilarginase Effect on Arginase one Deficiency Clinical Endpoints) trial and in a Phase II open-label extension study for patients with Arginase One Deficiency. Its AGLE-177, is a novel PEGylated, or polyethylene glycol modified, human enzyme engineered to reduce Homocystinuria.

Closing Price
$4.55
Day's Change
0.23 (5.32%)
Bid
--
Ask
--
B/A Size
--
Day's High
4.64
Day's Low
4.22
Volume
(Light)
Volume:
171,188

10-day average volume:
351,972
171,188

Company Profile

Aeglea BioTherapeutics, Inc. is a clinical-stage biotechnology company. The Company is focused on developing human enzyme therapeutics to benefit people with rare metabolic diseases. The Company’s product candidates include pegzilarginase and AGLE-177. The Company's lead product candidate, pegzilarginase, is a recombinant human arginase one that enzymatically degrades the amino acid arginine to lower arginine levels in patients with Arginase one Deficiency. Its engineered pegzilarginase with modifications that enhance the stability and arginine-degrading activity of the enzyme in human plasma. The Company is evaluating Pegzilarginase in a global pivotal Phase III PEACE (Pegzilarginase Effect on Arginase one Deficiency Clinical Endpoints) trial and in a Phase II open-label extension study for patients with Arginase One Deficiency. Its AGLE-177, is a novel PEGylated, or polyethylene glycol modified, human enzyme engineered to reduce Homocystinuria.

Valuation Ratios

Price/Earnings (TTM)
--
Price/Sales (TTM)
14.87x
Price/Book (MRQ)
2.20x
Price/Cash Flow (TTM)
--
TTM = Trailing Twelve Months
MRQ = Most Recent Quarter

Price Performance

Historic Growth and Share Detail

Historic Growth

No historic growth available.

Short Interest

December 2021
Current Month
822.1K
Previous Month
937.4K
Percent of Float
1.70%
Days to Cover
3.2619 Days

Share Information

AGLE is in a share class of common stock
Float
48.6M
Shares Outstanding
49.3M
Institutions Holding Shares
115
89.99%

Financial Statements

Balance sheet

Values displayed are in thousands.

Income statement

Values displayed are in thousands.

Cash flow

Values displayed are in thousands.

Company Officers

  • Russell J. Cox
  • Anthony G. QuinnPres.
  • Jonathan D. AlspaughCFO
  • Leslie SloanCOO
  • Steven WeberVP

Address

Insider Trading

During the most recent quarter, 294K shares were bought in insider trading.

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