Global Blood Therapeutics Inc
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Health Care : Biotechnology | Small Cap GrowthCompany profile

Global Blood Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is engaged in discovering, developing and commercializing therapeutics to treat blood-based disorders. The Company is developing its initial product candidate, GBT440, as an oral, once-daily therapy for sickle cell disease (SCD). The Company is evaluating GBT440 in SCD in a Phase III clinical trial of GBT440 in adult and adolescent patients with SCD. GBT440 inhibits abnormal hemoglobin polymerization, the underlying mechanism of RBC sickling. The Company is also engaged in other research and development activities targeted towards hereditary angioedema (HAE). The Company's GBT440 is an investigational drug that increases hemoglobin's affinity for oxygen by binding to the alpha-chain of hemoglobin. GBT440 has been observed to keep a proportion of sickle hemoglobin (HbS), in its oxygenated state, where it cannot participate in polymerization.

Closing Price
$50.55
Day's Change
0.00 (0.00%)
Bid
--
Ask
--
B/A Size
--
Day's High
51.54
Day's Low
49.33
Volume
(Below Average)
Volume:
492,223

10-day average volume:
555,216
492,223

Financial stocks fall, as XLF on track to snap 11-day win streak

9:34 am ET January 22, 2019 (MarketWatch)
Print

The SPDR Financial Select Sector ETF (XLF) fell 0.6% in morning trade Tuesday, putting it on track to snap an 11-session win streak, with 61 of 67 equity components losing ground. The financial ETF (XLF) has run up 10.7% during the win streak. Among the XLF's most heavily weighted components, shares of Warren Buffett's Berkshire Hathaway Inc. (BRKA) fell 0.4%, J.P. Morgan Chase & Co. (JPM) shed 1.1%, Bank of America Corp. (BAC) gave up 0.5% and Citigroup Inc. (C) lost 1.0% in early trade. The win streak is currently the longest since the record 13-day stretch ending Nov. 10, 2014, and it comes after about seven months after its record 13-session losing streak that ended June 27, 2018. The XLF has slipped 1.0% over the past three months, while the S&P 500 has declined 3.7%.

-Tomi Kilgore; 415-439-6400; AskNewswires@dowjones.com

(END) Dow Jones Newswires

January 22, 2019 09:34 ET (14:34 GMT)

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