ArQule Inc
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Health Care : Biotechnology | Small Cap GrowthCompany profile

ArQule, Inc. is a biopharmaceutical company that is engaged in the research and development of therapeutics to treat cancers and rare diseases. These drugs focus on the biological pathways implicated in a range of cancers and certain non-oncology indications. Its clinical-stage pipeline consists of approximately four drug candidates, all of which are in targeted patient populations. The Company's product candidates include ARQ 531, Miransertib (ARQ 092), ARQ 751, Miransertib (ARQ 092) and ARQ 751. ARQ 531 is a potent and reversible dual inhibitor of both wild type and C481S-mutant Bruton’s tyrosine kinase (BTK). ARQ 092 is a potent and selective inhibitor of protein kinase B (AKT), a serine/threonine kinase. ARQ 751 is a potent and selective inhibitor of AKT that is in Phase I clinical development for solid tumors harboring AKT, phosphoinositide 3-kinase (PI3K). ARQ 087 is a multi-kinase inhibitor designed to preferentially inhibit the fibroblast.

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UPDATE: Here's how the stocks held by Warren Buffett's Berkshire Hathaway have performed in 2019

7:29 am ET August 31, 2019 (MarketWatch)

UPDATE: Here's how the stocks held by Warren Buffett's Berkshire Hathaway have performed in 2019

By Philip van Doorn, MarketWatch

Winners include Mastercard and Costco, while Kraft Heinz is one of the worst performers

Whenever Berkshire Hathaway announces a change in its stock portfolio or CEO Warren Buffett comments about an individual company, it is big news.

Buffett turns 89 on Friday, and the most-covered story about Berkshire Hathaway's investment portfolio this year has been the continuing difficulties of Kraft Heinz (KHC). The company suffers not only from changes in consumer tastes, but also accounting problems (, a heavy debt load and an investigation by the Securities and Exchange Commission. Buffett has expressed regrets ( over Berkshire tremendous investment in the "old" Kraft and involvement in the 2015 merger with Heinz Co.

Among other investments, Buffett recently added ( to Berkshire's (AMZN) holdings, after the position was first made public in May.

Read:Buffett says Amazon stock purchase doesn't deviate from value-investing principles (Buffett%20says%20Amazon%20stock%20purchase%20doesn%e2%80%99t%20deviate%20from%20value-investing%20principles)

Berkshire also has been increasing its holdings of bank stocks. The company is the largest owner ( of Bank of America (BAC), with more than 10% of the common shares. Buffett said earlier this year that shares of large U.S. banks, including Berkshire holding JPMorgan Chase (JPM), are significantly undervalued by the market (

Berkshire sold its position in Oracle (ORCL) and trimmed its Apple (AAPL) holdings earlier this year.

In May, Buffett said he planned to "put a lot of money (" into energy-sector investments.

Berkshire portfolio winners and losers of 2019

Because of the continual changes in the portfolio, this list of Berkshire's 45 publicly traded holdings as of June 30 is sorted by total return this year, and includes longer periods measuring returns, regardless of when Buffett decided to initiate, add to or trim positions:

Company Ticker Total return - 2019 through Aug. 28 Total Return - 3 Years Total Return - 5 Years Total Return - 10 Years Total Return - 15 Years

StoneCo Ltd. Class A US:STNE 66% N/A N/A N/A N/A

Moody's Corp. US:MCO 54% 109% 146% 795% 650%

Restaurant Brands International Inc. US:QSR 51% 77% N/A N/A N/A

Mastercard Incorporated Class A US:MA 48% 194% 278% 1336% N/A

Costco Wholesale Corp. US:COST 45% 93% 176% 632% 850%

Charter Communications Inc. Class A US:CHTR 41% 60% 132% N/A N/A

Synchrony Financial US:SYF 39% 27% 33% N/A N/A

Mondelez International Inc. Class A US:MDLZ 38% 35% 66% 276% 298%

VeriSign Inc. US:VRSN 37% 172% 261% 1015% 1289%

Visa Inc. Class A US:V 36% 126% 245% 990% N/A

Procter & Gamble Co. US:PG 35% 52% 72% 213% 233%

Store Capital Corp. US:STOR 34% 44% N/A N/A N/A

Apple Inc. US:AAPL 32% 102% 119% 870% 9500%

American Express Co. US:AXP 26% 92% 44% 304% 242%

Travelers Companies Inc. US:TRV 24% 34% 74% 277% 507%

Liberty Global Plc Class C US:LBTYK 23% -16% -30% 166% N/A

United Parcel Service Inc. Class B US:UPS 22% 18% 39% 192% 143%

Axalta Coating Systems Ltd. US:AXTA 22% 1% N/A N/A N/A

Liberty Global Plc Class A US:LBTYA 22% -16% -29% 174% 268%

Goldman Sachs Group Inc. US:GS 21% 26% 21% 39% 164%

Coca-Cola Co. US:KO 18% 41% 56% 206% 285%

Globe Life Inc. AU:TMK 18% 40% 65% 405% 336% Inc. US:AMZN 17% 129% 419% 2032% 4322%

Delta Air Lines Inc. US:DAL 16% 68% 56% 757% N/A

Phillips 66 US:PSX 15% 35% 30% N/A N/A

U.S. Bancorp US:USB 15% 28% 39% 185% 170%

JPMorgan Chase & Co. US:JPM 12% 74% 106% 214% 298%

General Motors Co. US:GM 11% 31% 29% N/A N/A

Southwest Airlines Co. US:LUV 11% 46% 67% 544% 276%

PNC Financial Services Group Inc. US:PNC 11% 57% 69% 267% 249%

Liberty Media Corp. Series C Liberty SiriusXM US:LSXMK 10% 24% N/A N/A N/A

Bank of America Corp US:BAC 10% 79% 81% 64% -16%

Liberty Media Corp. Series A Liberty SiriusXM US:LSXMA 10% 21% N/A N/A N/A

Liberty Latin America Ltd. Class A US:LILA 8% N/A N/A N/A N/A

Sirius XM Holdings Inc. US:SIRI 8% 51% 74% 825% 163%

Liberty Latin America Ltd. Class C US:LILAK 8% N/A N/A N/A N/A

Suncor Energy Inc. US:SU 4% 12% -18% 15% 166%

M&T Bank Corp. US:MTB 3% 31% 31% 205% 124%

(MORE TO FOLLOW) Dow Jones Newswires

August 31, 2019 07:29 ET (11:29 GMT)

Copyright (c) 2019 Dow Jones & Company, Inc.

MW UPDATE: Here's how the stocks held by Warren -2-

Johnson & Johnson US:JNJ 2% 17% 43% 189% 242%

Wells Fargo & Co. US:WFC 2% 3% 3% 115% 137%

United Airlines Holdings Inc. US:UAL -2% 76% 71% 1165% N/A

Bank of New York Mellon Corp. US:BK -11% 7% 16% 71% 78%

American Airlines Group Inc. US:AAL -20% -28% -32% N/A N/A

Kraft Heinz Co. US:KHC -39% -68% -36% N/A N/A

Teva Pharmaceutical Industries Ltd. ADR US:TEVA -55% -86% -86% -84% -70%

Sources: Berkshire Hathaway filing, FactSet

Has Buffett lost his touch?

Shares of Berkshire Hathaway are down 2% this year through Aug. 28, compared to a 17% total return for the S&P 500. Berkshire's 15-year total return has lagged the S&P 500 slightly:

But check out this 20-year chart:

That is remarkable outperformance.

During Berkshire's annual meeting in May, when asked if he would recommend investors buy shares of the company or invest in the S&P 500, Buffett said: "I think the financial result would be very close to the same ("

Then again, Buffet, through Berkshire's tremendous hoard of cash ($119 billion in cash and short-term investments in short-term U.S. Treasury notes as of June 30), has tremendous power to scoop up bargains if the stock market falls. He displayed this power through his preferred-stock investments in Bank of America and Goldman Sachs during the financial crisis. These turned out to be extremely lucrative when the preferred shares were converted to common shares.

Don't miss:Seeking attractive dividend stocks? Here's how to separate winners from losers (

Create an email alert for Philip van Doorn's Deep Dive columns here (

-Philip van Doorn; 415-439-6400;

RELATED: Larry Swedroe: Why you should keep believing in Warren Buffett even though the stock market is crushing Berkshire Hathaway (

RELATED: Howard Gold: Investors should no longer bet on Warren Buffett (

RELATED: 50 best things Warren Buffett told investors over his first 50 years at Berkshire (

RELATED: Warren Buffett's reading list, from Benjamin Graham to football (

RELATED: It took Warren Buffett 20 months to sell his home--how to avoid that same fate (

(END) Dow Jones Newswires

August 31, 2019 07:29 ET (11:29 GMT)

Copyright (c) 2019 Dow Jones & Company, Inc.

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