Transcode Therapeutics Inc
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Health Care : Biotechnology |
Company profile

TransCode Therapeutics, Inc. is a ribonucleic acid (RNA) oncology company. The Company's lead therapeutic candidate, TTX-MC138, is focused on treating metastatic cancer. TTX-MC138 comprises proprietary iron-oxide nanoparticles and oligonucleotides that specifically target microRNA-10b. The nanoparticles serve as the vehicle to deliver oligonucleotides to metastatic cancer cells. The magnetic properties of these nanoparticles allow for monitoring of their delivery using non-invasive imaging. Its pipeline products also include TTX-siPDL1, TTX-siLIN28b and TTX-RIGA. TTX-siPDL1 is a checkpoint inhibitor targeting programmed cell death protein ligand 1 (PD-L1). TTX-RIGA utilizes its delivery system and is intended to activate the RIG-I signaling pathway to elicit an immune response to eliminate and/or reduce the risk of developing disorders associated with abnormal apoptotic or differentiative processes, by triggering an immune response that targets developing cancer cells.

Closing Price
Day's Change
0.23 (8.55%)
B/A Size
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(Above Average)

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VOTE: ESG Activism in an ETF

4:57 pm ET November 11, 2021 (Zacks) Print

  • (1:00) - Engine No. 1 and the Exxon Campaign
  • (7:15) - Engine No. 1 Transform 500 ETF: VOTE
  • (16:00) - How Does VOTE Fit Into Your Portfolio vs. Other ESG Investments
  • (21:45) - How Does Engine No. 1 Choose Which Campaigns To Pursue?


In this episode of ETF Spotlight, I speak with Yasmin Dahya Bilger, head of ETFs at Engine No. 1, about activist investing through an ETF. The activist investment firm had sent shock waves through Corporate America in May when it targeted Exxon Mobil XOM and successfully placed three candidates on the board of directors.

The Engine No. 1 Transform 500 ETF VOTE, which started trading in June, intends to encourage transformational changes in companies through shareholder activism. The fund invests in 500 of the largest US public companies and comes with an expense ratio of just 0.05%.

VOTE is an excelent alternative to standard S&P 500 ETFs for ESG focused investors since they can get a similar financial performance while participating in efforts to bring transformational changes in portfolio companies. Microsoft MSFT, Apple AAPL and Alphabet GOOGL are the top holdings in the market cap weighted ETF, which has already gathered about $250 million in assets.

Tune in to the podcast to learn more about this unique activist approach to sustainable investing.

Make sure to be on the lookout for the next edition of the ETF Spotlight! If you have any comments or questions, please email

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report
Apple (AAPL): Free Stock Analysis Report
Microsoft (MSFT): Free Stock Analysis Report
Exxon Mobil (XOM): Free Stock Analysis Report
Alphabet (GOOGL): Free Stock Analysis Report
ENGNO1 TRFM500 (VOTE): ETF Research Reports
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