Aeglea Bio Therapeutics IncChange company Symbol lookupSelect an option...AGLE Aeglea Bio Therapeutics IncPTOCU Pine Technology Acquisition CorpBLUE bluebird bio IncENSV Enservco CorpULIHF United Laboratories International Holdings LtdABOIF Aboitiz Equity Ventures IncVYNE Vyne Therapeutics IncCEAD CEA Industries IncBFRI Biofrontera IncARW Arrow Electronics IncGo
Aeglea BioTherapeutics, Inc. is a clinical-stage biotechnology company. It is focused on human enzyme therapeutics to treat people with rare metabolic diseases. Its lead product candidate is pegzilarginase, which is a recombinant human arginase 1 that enzymatically degrades the amino acid arginine to lower arginine levels in patients with Arginase 1 Deficiency. It has engineered pegzilarginase with modifications that enhance the stability and arginine-degrading activity of the enzyme in human plasma. Its second product candidate, AGLE-177, is a novel PEGylated ( polyethylene glycol) human enzyme engineered to degrade free homocysteine and homocystine in patients with Homocystinuria. The Company is evaluating Pegzilarginase in a global pivotal Phase III pivotal PEACE (Pegzilarginase Effect on Arginase one Deficiency Clinical Endpoints) trial and Phase I/II open-label extension trial. It is also conducting a Phase I/II clinical trial for the treatment of patients with Homocystinuria.
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